Durban
Durban was the big jump in my career. I
left a comfortable position in Cape Town to start a new leading role in an
unexplored part of South Africa
Durban is in Kwa-Zulu-Natal. On Christmas
day in 1497, Vasco da Gama, a Portuguese explorer, first discovered Durban. It
was inhabited by several African tribes. There were a few
brief visits mainly by shipwrecked sailors, but there was no development
until the early 1820's when Britain looked for a port to trade with the local
tribes. They were keen to trade mirrors, blankets, beads and tobacco for ivory,
horns and hides. The hinterland is rich in iron and coal and a large port was
needed to expand the industrial development,
Durban is now the major port on the East
Coast of South Africa. Since it had been
settled by the English, this remained the dominant language and it still
maintains its colonial heritage. It has
a large African population and also a sizeable Indian population who emigrated
from India.
The weather is hot and tropical with a
monsoon climate. The summers are very
hot and humid: in the summer the rain breaks the torrid heat at 4 p.m. with
torrential downpours that would then clear 2 hours later. The winters are mild and almost
nonexistent. We bought good air
conditioner to ameliorate the intense humid heat.
The vegetation is subtropical forest,
part of the coastal echosystem and scrubland in the drier areas but with thick
rich evergreen foliage.
We left Cape Town at the end of December,
1967. When I received the appointment,
Maurice Nellen, one of the senior cardiologists in Cape Town, made two
suggestions: to buy a new suit and to
acquire a Jaguar motor car. I went to visit
my bank manager and he suggested that since I had only 600 pounds left in the
bank, that I buy his second hand Ford Zodiac. It was a perfect offer and the
car was in excellent condition. We sent my
old car, the yellow Anglia with its cutback window by train to Durban, with our
furniture and household belongings and we embarked in the Zodiac on our 2-day
journey. We had 4 children, a small dog, and 2 hamsters. It was a pleasant drive along the Garden
route with its thick foliage and magnificent views, past George, Knysna and
Port Elizabeth and we overnighted near East London. We arrived in Durban the following
morning. The children were exhausted but
we had a partially furnished house which we had rented from Brian Gibbs'
landlady. Brian Gibbs was my predecessor at Wentworth, but when a new younger
chief was appointed, he decided to move to Pietermarizberg where he could earn
a little more in private practice.
The house was old but spacious with 3
large bedrooms, two large living rooms and a wrap around verandah. It was located on the top of the Berea, a
tall ridge overlooking Durban and the sea.
We had an uninterrupted panoramic view of the beach, the docks, the bay
and the Bluff peninsula. It was cooled by a stiff sea breeze in the late
afternoons. It had a large garden with a well-kept lawn, an ideal playground
for the children.
We bought some new furniture and were
ready for our new adventure. The car and
our personal belongings arrived two days later and we soon felt at home. The house was located strategically in a pleasant
upper middle class neighborhood. The synagogue and the Jewish primary school
were around the corner and within walking distance; the bank was close by and
next to it, a large shopping center.
After 3 months, I persuaded the landlady, who was living in a senior
citizens home to sell us the house. It was an ideal family home and needed only
a fresh coat of paint. The children were
enrolled in the nearby parochial, Jewish school, and they were now set on their
new educational trajectory. Aileen was
pregnant and Sharon was born a few months later at Addington Hospital.
The medical school was very different
from Cape Town. The students were predominantly non-white, taught by the senior
staff of expatriate English professors.
The medical staff dressed in white bush jackets, with white shorts and
immaculately polished white shoes and long socks. They were anti-establishment but typically
colonial. It was a contrast to the
universities in Johannesburg and Cape Town, and quite different from the
Afrikaans medical schools in Pretoria, Bloemfontein and Stellenbosch. In South Africa Medical Services and
education were the responsibility of the 4 different Provinces, the equivalent
of the States in the United States. The Provincial Administration, was
controlled by the English white majority although Dr. Willem Botha, the
Director of Medical Services was a little distant from the English controlled
medical school. Ben le Roux, the head of
thoracic surgery, had already earned his respect and acquired his trust and
support and I entered this small circle.
Sam Disler, the Hospital Director, was also Jewish so that we created a
friendly and supportive relationship which in part bypassed the medical school.
Sam and I soon became close friends. We had a sympathetic ear in the Provincial
Administration for the development of the hospital.
Wentworth Hospital had been built as a
temporary army hospital during World War II.
It had a large spread out campus on the top of the ridge of the Bluff, south
of Durban itself and overlooking the sea and the local airport. It was designed
as a series of long Nissen huts that served as individual wards. The single
story wards were joined together by interleading open, but covered corridors
like verandahs. After the Second World War,
it was converted into an infectious diseases hospital and specialized in treating
tuberculosis. It needed thoracic
surgeons to undertake the tuberculosis surgery and then attracted patients with
other chest problems. Later the
Administration added closed heart surgery.
When the new, effective antibiotics controlled tuberculosis, the
Administration decided to convert the Hospital into a large single regional center
with specialized services for the entire Province for cardiothoracic and
neurosurgery and later cardiology. The
single floor hospital had the great advantage that it was easy to clean and
undertake simple renovations. The
Administration had also planned a new regional obstetric center, but with a
little persuasion it was converted into new operating rooms and wards for heart
surgery.
The medical service was planned on the
British system where a single regional hospital such as Papworth Hospital near
Cambridge servs a large region without reduplication of facilities. This meant that we were a large reference
centre for the entire Province.
Our offices were new, located in a
prefabricated building. Ben le Roux, the chief of cardio-thoracic surgery, and
I had two adjacent offices which allowed very close personal interaction and cooperation.
Our doors were never closed so that there was a continuous professional
dialogue. Ben was a fine honest colleague with an open mind, and soon we worked
as a closely knit team.
Ben was a perfectionist and absolutely predictable.
He would leave home at 6 a.m. in the morning, swim at the nearby Brighton beach
off the Bluff peninsula, return to the hospital at 6:40, shower and shave his
body, make rounds at 7 and by 8 he was scrubbed and ready in the operating
room. Surgery was never delayed. Nurses,
technicians and patients were all ready before he arrived. He was a master of order and discipline.
His father had been head of Classics at
the University of Cape Town and Ben trained at the University of Edinburgh. He had been the senior registrar at the Royal
Infirmary and Andrew Logan, the chief of surgery, who joined us some years
later, would tell that if he left patients unoperated on Friday afternoon they would
have surgery over the weekend. Ben simply put together a team of on duty nurses
and surgeons, completed all the operations and cleared the wards. All the
patients had undergone an operation by Monday morning. He was a natural leader.
He was a quick and expert, cutting, thoracic
surgeon, and between major operations would undertake all the bronchoscopies
and bronchograms while the anaesthetists
were inducing the next patient.
Initially he was uncomfortable with open
heart surgery, and we brought Andrew Coleman to care for the patients. Andrew
was a British trained anesthetist, well trained in cardio-respiratory
physiology. He took over the heart-lung machine and the physiological
monitoring and care of the patients in the operating room and continued with
the post-operative care. This was a
great success and the new combination of good cardiology, precise surgery and careful
post operative care produced excellent results. Later Ben was joined by Mike
Rogers, an experienced cardiac surgeon who had trained with Donald Ross at the
National Heart Hospital in London. He introduced coronary artery bypass surgery
and homograft valves. They brought young registrars from Edinburgh and Cape
Town and trained a new generation of young surgeons.
The department had several good and
established cardiologists. Bill Winship
came from an old Durban family and was very active in the pediatric department
at Addington Hospital. Ronnie van der
Horst was in private practice and a little rough, but he had exuberant
enthusiasm, golden hands and, with supervision, he was excellent in the cath
lab. He had trained at Cook County
Hospital in Chicago, and understood the anatomical intricacies of congenital
heart disease. Our large volume of
patients allowed us to put together many large series of unusual
malformations. He worked hard in private
practice but we would spend Sunday afternoons together, and while the children
played outside in the garden, we prepared and wrote a series of interesting
papers. He also followed, documented and
analyzed the data of children who underwent valve replacement surgery.
Gerald Lapinski was the other adult
cardiologist. He was disappointed at not
receiving the appointment of Departmental head and left for full time private
practice when they opened a catheterization laboratory at St Augustine's private
hospital. I was left alone with the
adults except for Tom Armstrong, an enthusiastic and experienced older
physician in practice, but with great vitality and he was always ready to learn
new tricks.
The catheter lab was run by Arthur
Skowron, a sharp, intelligent physicist, who ran the lab with an iron
hand. When I introduced the new equipment
and procedures he felt that he could not maintain the new accelerated pace and
retired gently.
Cardiology needed a new look. I understudied Val Schrire very carefully
after I had turned down the appointment in Melbourne and I came to Durban with an
exact plan for developing the department: patient care and service, teaching
and research.
The wards were repainted and equipped
with new physiological monitoring equipment.
Three patients in each ward had ECG monitors with a slave monitor in the
nurses' office. We bought new ECG
machines and built a new wing for radiology, a new catheter lab and meeting
rooms. There was no budget for new buildings so we simply built an extended
prefabricated wing which was cheaper and did not require extensive budget allocations
and delays for approval by the Provincial Council.
CGR, Siemans and Philips, the three major
X-Ray companies competed for the new X-Ray contract. They asked the Provincial Administation
to send me to Europe to learn about their equipment and see their best
installations. I spent two months in Paris, Einthoven, Holland and Stockholm
visiting their factories and local hospital installations. It was my first
visit to the continent. Paris was difficult because of the language, Einthoven
and the Dutch Hospitals in Rotterdam, Amsterdam and Leiden were very exciting
because Gotsman, the "eager beaver" soon discovered how the machines
worked and updated his radiology and I understood the language. The Elema
factory in Stockholm and the Karolinska Hospital fascinated me. It was
midwinter and I do not remember seeing the sun. The medical language of the
hospital was English, but there were three major sections: cardiology for the
diagnostics and catheterization, radiology for the angiography and left heart
studies, and a pacemaker group who dealt with the arrhythmias. The surgery was
excellent. I also spent time at Elema studying their new pacemaker technologies
and the large roll film and cut film changers. It was the most intense learning
period of my life and I returned home with new knowledge and interesting ideas.
We chose the Phillips system as the
company offered us a bi-plane system for the price of a single plane. Morris Reznick was an outstanding Phillips
representative and technician and after studying the competition: CGR, Siemans
and Elema I thought that Morris would provide the most effective service. We
planned and ordered a Philips biplane room.
It had a 6/9 inch intensifier in the one plane and a 6/41/2 inch
intensifier in the second plane. The
larger intensifier provided a large field to cover the entire heart and was
suitable for ventriculography, while the smaller one provided more
magnification and was ideal for greater resolution for coronary
angiography. The biplane system reduced
the number of contrast injections in children with complex congenital heart
disease. Phillips had not succeeded in
synchronizing their bi-plane system.
Morris worked in the lab every Sunday until the unit worked effectively
and because of his superb ability he ultimately became the South African, national
general manager of their radiology division. We worked together to optimize the
photography, experimenting with lens apertures of the camera, and varied
exposure settings, using different films and development protocols. Eventually, we had very high quality pictures
and I emerged as an expert on image processing and photography. We bought a new multi channel, NEP
photographic recorder for very high frequency registration of the ECG, pressure
tracings and phonocardiograms. We introduced new clinical forms for patient
records and a complex filing system and had a complete file of all the patients
which we archived in our administrative block.
We had two major out-patient clinics a
week. On Monday morning patients who
were referred from all the Provincial Hospitals would arrive by car, bus or
ambulance, and we would see up to 60 patient referrals. Each patient would be evaluated and returned
home with a detailed report and suggestions for treatment. The patients who needed further specialized
investigation would be hospitalized and then undergo catheterization and
surgery if needed. We maintained a
flexible bed status so that there were always vacant beds.
We had a similar clinic at King Edward
Hospital which was the main teaching hospital.
These clinics demanded great concentration and were physically hard and exhausting.
The registrars would see many of the patients but I would examine most of them
and consult on the final diagnosis and treatment plan.
Patients who were seen by their private
physicians were admitted as needed, although all the services in the hospital
were free. This was the great advantage
of the hospital and the full-time physicians including myself received a small
fixed salary. When I started I received
the equivalent of $9,000 a year without any extras.
We set up training programs for the
nurses and technicians and within a short time we had a high powered modern
establishment.
In retrospect it is hard to understand
how a young, 32 year old physician, only 10 years out of medical school, could
undertake such a major responsibility of running this large unit and making important
life and death decisions while building the best infrastructure in the country.
I am not sure whether it was good fortune or simply intensive training with
mature insight, but the department blossomed and I soon received the confidence
and backing of my senior staff, the administration and the local medical
practitioners. The hospital had an
enormous drainage area of more than 5 million people and we were the sole
tertiary reference center for the entire province. The working schedule was
exhausting. I would arrive at about 8AM, make a daily round with the registrars
and then continue in the cath lab 3 days a week or undertake an outpatient
clinic. Often there was a midday ward round to see the new admissions or follow
the very sick patients and then continue in my office with the administrative chores.
Then another late afternoon round allowing me to settle in my office with a bar
of chocolate and coffee to review the latest research data or prepare a paper.
The day finished between 6 and 10PM. I knew every patient personally, and Pam
Peters, my secretary, would type the reports and deal with the research
material and papers. I used a tape recorder and this saved much time.
The main medical problem was acute
rheumatic fever. Acute infections of the throat were common because the
children were raised in overcrowded homes, often in huts. Medical services in the country and small
villages were sparse and treatment with penicillin often delayed. The rheumatic fever ravaged and severely
damaged the hearts in the young children and adults. This was a common and unfortunate
outcome. We had many sick children with
leaking valves, grossly enlarged hearts leading to severe heart failure. They would be admitted for stabilization and
then undergo urgent valve replacement.
The results were dramatic and these large, dilated hearts would shrink
and return to normal size. The metallic
artificial valves were thrombogenic and the children needed anticoagulation
with Warfarin. This required careful monitoring of their anticoagulant status
with regular fortnightly blood tests. Many of the children lived in remote
country districts and their poorly educated parents were unable to maintain optimal
anticoagulant control. We were plagued
by stuck valves due to clots on, or in, the valves, or bleeding from excessive
treatment. Ben and I had an emergency
service to operate on stuck valves, and a child who would present to the
hospital with acute, new symptoms at 10 p.m. would undergo immediate surgery
and have a new valve implanted, 2 – 3 hours later. Ben and I were tireless.
Mike Rogers had learned how to prepare
homograft valves in London, so we bought preformed frames and harvested aortic
valves from subjects who had been killed in motor car accidents or died after
severe trauma. We would then mount the valves in the frame, sterilize the new
valve and implant the appropriate sized valve in the patient. We soon found it difficult to obtain informed
consent from the family to harvest the valves from the deceased donors. The
Provincial Administration amended the law to simplify the problem. The donors were dead and we had at least a
12-hour window for harvesting. It
resembled removing a cornea after death.
The immediate surgical results were
excellent. The valves had good
haemodynamics and the patients became symptom free. Many young women in whom a homograft had been
placed, underwent successful pregnancies since we were able to stop the
anticoagulants after 6 months.
Unfortunately, the natural repair and renewal process of the implanted
prosthetic valve was imperfect, and the cusps either calcified after 4 or 5
years or developed little cracks and fissures and then degenerated. This was a slow process which lasted several
months. When the patients returned with new symptoms we could prepare them gently
for a second or even third operation.
We studied the pathophysiological changes
in the patients in great detail and produced a series of publications to
describe the natural history of these new diseases; rheumatic heart disease which
had been modified by an operation. This included clinical studies, changes in
the ECG and X-ray including careful studies of changes in left ventricular volumes
and ventricular function. The key question was; was the ventricular function
reversible and would it return to normal? The great confounder was recurrent
rheumatic fever which often refused to remain dormant despite adequate
antibiotic chemoprophylaxis. The large patient cohort formed an unbelievable
human laboratory which allowed us to study in detail the dynamic changes in
these patients.
Many patients had severe rheumatic mitral
stenosis (narrowing of the valve) and we undertook scores of mitral
valvulotomies. Ben was an expert and
after 3 years we were joined by Andrew Logan who had retired from the chair of
thoracic surgery in Edinburgh. He was a
tall, bald erect man with large hands and a firm stride. The operation would never
last more than an hour. He opened the
chest in the fourth intercostal space, pushed the lung backwards, opened the
pericardium, placed a purse string suture on the left atrial wall, opened the
atrium, passed his index finger gently into the mitral orifice to assess the
size and status of the valve. An
assistant would place another purse string suture at the apex of the left
ventricle. He opened the ventricular wall, passed a special dilator (Logan or
Tubbs) which looked like an inverted scissors, guided it with his finger into
the mitral valve orifice, opened the dilator to a predetermined size and
separated the fused mitral valve cusps at the commissures. He would then withdraw the dilator tip into
the ventricle, assess the result with his finger and then make a second
dilatation if the first one was inadequate.
Once the valve had been opened adequately, he would withdraw the
dilator, tie the left ventricular purse string suture and then remove his
finger and tie the left atrial incision. Suturing and closing the pericardium
and the chest wall took another few minutes and the patient returned to the
recovery room.
I
became an expert in making a correct preoperative clinical diagnosis. This was based on palpation, (slapping apex
beat and right ventricular lift), auscultation (close opening snap,
mid-diastolic murmur with presystolic accentuation and loud first heart
sound). The ECG showed right axis
deviation and left atrial enlargement, and the x-ray a large left atrium and
pulmonary venous congestion. I learned
that a calcified valve and even trivial mitral incompetence were
contraindications to operation. We had
no echocardiography and rarely made errors in diagnosis. Patients had routine phonocardiography and we
could assess the severity of the valve obstruction. My training in London and
later with Val Schrire and the other cardiologists in Cape Town, all of whom
had trained with Paul Wood had turned me into an intelligent clinical
cardiologist, with sensitive fingers for palpation and carefully tuned ears for
precise auscultation. We catheterized many of the patients to confirm the
diagnosis. The echocardiogram had not been introduced and I became expert in
recognizing patients with calcification of the mitral valve and trivial
insufficiency who were unsuitable for a closed valvulotomy.
Again, this experience was a fruitful
basis for research particularly the evolution and regression of pulmonary
hypertension. We collected and indexed the patients, carefully, comparing all
the clinical findings. The ward rounds were slow and thorough and all the young
registrars in training became superb clinical cardiologists.
The Province was also an untapped
reservoir of children with unoperated congenital heart disease who needed
treatment. We had a large population and
investigated the most complex syndromes.
Ben and his colleagues improved their surgery and we soon had excellent
results. Ronny van der Horst documented and classified the patients and with my
experience from the Children's Hospital in Birmingham we soon recognized the
unusual syndromes like congenital mitral stenosis, cor triatriatum and the
"scrambled egg syndrome" where the body cannot recognize right and
left orientation of the organs and this causes the most complex cardiac malformations. Our
surgery was good and many patients with severe congenital malformations
underwent a successful operation and were returned to normal life
Mike Rogers was good at coronary artery
bypass surgery which requires careful and accurate microsuturing. I now became very experienced at coronary
angiography and soon we had a large program of coronary bypass surgery. We were
joined by Peter Richardson, a cardiologist from Vancouver who had been a Fellow
at the Hammersmith Hospital. He introduced us to the transfemoral percutaneous
Judkins technique using special preformed catheters and soon we abandoned the
more difficult Sones technique. John
Barlow, the senior cardiologist in Johannesburg, initially, was opposed to coronary
artery bypass surgery and Chris Barnard inn Cape Town took a long time to adapt
to microsurgery. We were the only major unit in the country with this program
and soon we were drawing patients from Johannesburg and Pretoria who were
outside our Provincial territory.
The Provincial administration was impressed
by our success and national reputation and opened their coffers to provide
money for expansion, staff and medical equipment. We were a modern hospital, with excellent
facilities, working in a third world community.
I now started to attract medical
trainees. They were all excellent and
continued their very successful careers. Justin Silver, grew up in Durban and
brought with him from Johannesburg two other young doctors . Denise Kitchiner and Basil Lewis
arrived the following year. Basil was quite outstanding. His father was a successful furniture
merchant in Springs. He was tall and
thin and when he finished the army he came to Durban. He was a fast learner, dexterous in the cath
lab and not afraid of hard work. We
would retire to my office in the late afternoons and put together the research
results. I would leave at 10 p.m. and he
would work all night, so that the data was on my desk in the morning. My mind was spinning with questions and new
ideas of pathology, physiology and treatment. We worked in academic isolation
punctuated by annual trips abroad.
The next phase was studying the
indigenous diseases in the local population. Congestive cardiomyopathy was endemic and the
commonest cause of heart failure. We set
up a program to study the disease in detail and understand the mechanisms of
heart failure due to heart muscle disease.
We did not know the cause of the disease: was it a genetic or viral? Despite years of subsequent study, we are no
closer to understanding the etiology of the disease in the African population.
Congestive cardiomyopathy was a very interesting and common disease. The
patients would develop heart failure in early adult life and after an
intercurrent event would develop congestive heart failure. They had a large
left ventricle, with the apex beat far beyond its normal limit. They had a
palpable early diastolic apical knock corresponding to a loud third sound,
often an apical pansystolic murmur due to functional mitral incompetence and
altered systolic timed intervals a sign of a failing left ventricle. The ECG
showed left ventricular hypertrophy, usually with marked left axis deviation
and ventricular conduction disturbances.The chest Xray showed left ventricular
enlargement, often left atrial enlargement and pulmonary venous
congestion. The angiogram showed a
greatly dilated ventricle with large end-diastolic and end-systolic volumes and
a very low ejection fraction. The left ventricular end-diastolic pressure was
elevated and all the direct and derived indices showed abnormal systolic and
diastolic ventricular function.
We were able to treat the patients for
many years with simple antiheart failure medications. Progressive cardiac enlargement, increasing
mitral incompetence, atrial fibrillation and ventricular ectopic beats, and
deep vein thrombosis carried a poor prognosis.
These patients provided a wealth of
material for studying the natural history of left ventricular dysfunction. We
studied the clinical syndrome, using external markers such as the chest x-ray,
ECG, physical examination and timed intervals and also by cardiac catheterization,
and again produced a series of publications on the subject. We were fascinated by the derived indices of
left ventricular pressure changes and measuring ventricular volumes at
angiocardiography. We looked at both
diastolic and systolic function of the ventricle. Arnold Weissler from Detroit had worked on
the left ventricular indices and shown that the pre-ejection period was related
to the iso-volumic contraction period and was prolonged in left ventricular
dysfunction. The left ventricular ejection time was decreased when the stroke
volume fell. This became our standard
for assessing left ventricular dysfunction. Once we had established our
techniques, we looked at patients with rheumatic valve disease before and after
corrective surgery. Basil made the recordings on our three channel Philips
hot-stylus recorder, I measured the intervals with a compass and Ray Everson would
punch the cards for the university NCR computer. He wrote the software and we
had highly significant statistical correlations. We were very excited by our results.
Later when we presented the data at a
meeting in Philadelphia we met the advance guard of the echocardiographers and
Basil and I re-routed our trip to Boston to learn the new speciality from
Roberta Williams who was then the rising star at the Children's Hospital. It
was an easy introduction to a brand new science.
There were other interesting indigenous diseases
such as subvalvular left ventricular aneurysms. Syphilis was endemic and many
patients were untreated so that the tertiary disease was common causing
aortitis and ascending aortic aneurysms.
Tuberculous pericarditis was common and
we saw patients in the early stages with large pericardial effusions often with
severe tamponade, but when seen later, had developed constrictive
pericarditis. We aspirated the large
effusions and decorticated the constrictions at surgery. These procedures were always accompanied by
careful hemodynamic measurements and angiography and we described in detail the
clinical findings and special tests. We wrote the literature in this field. One
of my registrars was involved in political activity and had to flee the
country. He was working on the pericardial
effusions: the data disappeared to England with him and we never published the
final paper. The hemodynamic studies
were very sophisticated. We placed a
catheter in the pericardium for aspirating the fluid, a second catheter in the
right atrium together with a flow meter and via a transseptal puncture another
catheter in the left atrium. We
constructed pressure volume curves of the pericardium together with the
associated disturbances in hemodynamics and blood flow at rest and during
respiration. It was possible to show
that the compliance of the pericardium depended on the volume of fluid. Large effusions were associated with very
compliant pericardiae and smaller effusions with tense noncompliant pericardium. Removal of 20% of the effusion, no matter how
large it was, would abolish the tamponade.
The next program was heart
transplantation. Chris Barnard was
forging ahead with great success in Cape Town.
We had so many patients dying from heart failure and I was so impressed
by the results of transplantation that I was determined to set up a
program. Botha provided us with a
sterile suite and we were ready to go.
Ben went to Cape Town to learn the surgical techniques. Our first patient was Aaron Hlongwane, a
35-year-old Bantu gentleman with intractable heart failure from
cardiomyopathy. We had a suitable donor
and opened his chest. Unfortunately, we
were not certain whether the donor had complete brain death. We closed his
chest and I felt such a responsibility for the unnecessary thoracotomy that I
treated him personally until he passed away two years later. He became my personal friend and patient. The next patient was Martin Hands. He also had severe heart failure after 3
major heart attacks. The operation was a
great success and he survived for a few months until he succumbed from acute
rejection. We continued the program for
another year until it became obvious that the then, current immunological
program, was inadequate to prevent long term rejection and we would have to
wait until cyclosporine was introduced. Mr Myburgh was our next candidate but
we could not find a suitable donor. We
had many other potential candidates. We
waited until October, 1969 when we found a donor for Mr. Dan Stoltz. He had severe coronary heart disease and
intractable heart failure. We had a
potential donor from the neuro surgery department but we waited a few days
until we were certain that the brain death was irreversible. Tensions rose in the hospital as Mr. Stoltz
had been so ill and we weren't sure that he would survive. The donor, Mr. Ian Taylor, had a sudden cardiac
arrest. The neurosurgical team
unsuccessfully tried to resuscitate him.
Mr Stoltz had already been prepared and the sterile rooms were
available. Team One took Mr. Taylor to
one operating room, to harvest the heart
while Team Two prepared Mr. Stoltz; a rapid induction, his chest was opened and
he was connected to the heart—lung machine.
Mr. Stoltz's heart was removed and replaced by the new donor heart. The new heart was weakened by the prolonged
resuscitation and the recovery was very slow.
We worked very hard for the next few days but his blood pressure
continued to fall and was unable to maintain a good cardiac output and he
died. The family was shattered by the
tragedy, then Ben became very despondent.
The publicity penetrated his iron clad exterior, so that the anticlimax
after such a long period of waiting deterred him from further procedures. Heart transplantation had survived its
initial wave of enthusiasm, and would need to wait for new effective
immunosuppressive drugs. Today, heart
transplantation is one of the best operations we undertake with excellent
ten-year survival.
The transplant program in Durban produced
a violent debate in the local press and also at the medical school. Fortunately, Botha, the Director of Medical Services
was very supportive; we survived the local criticism and gained a very good
medical reputation.
We also started a pulmonary program but I
was so busy with cardiology that I was unable to develop it to the full.
We were supported by a good pathology department
and our pathologist, Annie Kalachurim, was very enthusiastic. We had a regular Friday clinico-pathological
meeting. She made meticulous
post-mortems and was very careful and observant examining the heart. Unfortunately, she had difficulty writing
papers, so that we had very few publications.
Together we learned a great deal about our local diseases, particularly
cardiomyopathy.
The big academic event was the annual
meeting of the South African cardiac society in Durban. I was determined that
it would be an outstanding event in 1972 and we invited a powerful faculty from
abroad. My own interest was Paediatric cardiology so that we brought Alex Nadas
from Boston, Brian Barrett Boyes, the paediatric surgeon from Green Lane
Hospital in Auckland, George Burch, the editor of the American Heart Journal
from New Orleans, because of his deep interest in cardiomyopathies, Morrow, the
chief of cardiac surgery at the NIH in Washington and the expert on septal
ablation in hypertrophic cardiomyopathy. Electrophysiology was a new emerging specialty
so we brought two experts from London.
The meeting was held at the medical
school and we had a full turn out of all the cardiologists in South
Africa. My department presented 13
papers. I was run off my feet, managing
the Congress, the program, rehearsing our presentations and preparing the
slides and looking after the visitors.
Alex Nadas was very impressed with our
work and the range of patients we were seeing, and this formed the basis of a
long term professional and personal relationship. George Burch was fascinated by our cardiomyopathies,
our studies on pericarditis and our valve surgery. In later years he would introduce me as the
"crazy cardiologist" who put metal valves into children. Bryan Barrett—Boyes taught us a great deal about
cardiac surgery including the use of deep hypothermia reducing body temperature
to 12 degrees centigrade so that one could stop the heart and protect the brain
for periods of up to one hour. This
permitted correction of complex congenital heart lesions. The Congress was a great success and we
finished with a safari and a visit to the wild animals in the Kruger National
Park.
The academic progress was a little
slow. We were finishing many research
programs and I was a little impatient with delays in publication. The journals abroad would keep the papers for
a year for review, and we cut corners and published many of the articles in the
South African Medical Journal.
At this stage it is interesting to stop
for a brief interlude and review my journey in Cardiac Pathophysiology. It
started in London with the variability of high blood pressure and its influence
by sympathetic and parasympathetic stimulation and inhibition.Then I learned
about cardiac output and its measurement with Coomasie Blue dye dilution
curves. This needed an understanding of
volumes of distribution and exponential decays and their mathematical
analysis.
Simple cardiac catheterization needed an
understanding of cardiac hemodynamics.
In Birmingham I learned how to measure
cardiac output at rest and on exercise using the Fick principle, variations in
oxygen uptake and then the distribution of regional blood flow. Ken Donald and John Bishop had been working
on this for a few years when I arrived in Birmingham and I joined their
research group. Ken Donald left for
Edinburgh and his personal enthusiasm faded a little. Melville Arnott the head of the department,
believed that the lungs and pulmonary circulation were an integral part of
heart disease and Peter Harris, the reader, was preparing a monograph on the
pulmonary circulation. I entered the
pulmonary physiology research laboratories where we examined every aspect of
respiratory function. I was soon
versatile at all the techniques since the laboratory was very well
equipped. With discussion and reading I
understood these complicated interrelationships. I also understood how each machine
worked. I complemented my knowledge by
attending the University of Aston in the evenings where I learned electronics,
physics and more advanced mathematics.
I learned statistics in the
department. I carried my slide rule in
my pocket and learned how to use the simple mechanical calculator. All the statistics were calculated long hand
and I made long lists of measurements, their squares, their means and finally
calculated long hand all the formulae.
We then studied pulmonary regional
ventilation, blood flow and matching, the diffusing capacity of the lung and
respiratory mechanics using the body plethysmograph. I now understood how the lungs reacted in
heart disease.
In the operating room I came to
understand blood volume and cardiac function.
The simple changes that occurred when a patient went on or came off
cardiopulmonary bypass were related to the amount of bleeding, the priming
volume of the machine, and the distribution of fluids and blood between the
machine and the patient. Many patients
were dehydrated and fluid depleted and their blood pressure fell when they went
on bypass. At the end of the procedure
it was necessary to monitor blood and venous pressure and transfuse the patient
to obtain an optimal blood volume, blood pressure and cardiac output. This could also be modulated by the function
of the left ventricle after surgery. I
had recorded miles of tracings and made a careful analysis of these complex
interactions. Today, this part of the
basic training of any young cardiac surgeon.
Later, John Kirklin introduced his method of titrating by numbers when
the patient was weaned from bypass.
My
studies with congenital heart disease showed how the heart developed and
dilated or remained underdeveloped because of poor flow, and this we
interpreted in the chest x-ray and later in the cine angiogram. The cine angiogram with its fast rate of
exposure showed exactly how the heart contracted and I studied right
ventricular outflow tract dynamics in Fallot's tetralogy. It also showed shunts and chamber and vessel
enlargement. I studied poststenotic dilatation
of the pulmonary artery in pulmonary stenosis and aortic dilatation in aortic
stenosis and incompetence.
In Cape Town we were very interested in
the chest x-ray which showed chamber enlargement or underdevelopment as part of
the cardiac pathology. I also examined
heart volumes as a measurement of cardiac enlargement and showed how it changed
after a successful repair operation on a valve or congenital abnormality.
When I arrived in Durban I became a free
spirit. I was my own navigator. I could determine priorities and set my own
trajectory. I was constrained by the
University, the Provincial Administration, my colleagues and the patients. But the University was distant and did not
interfere. The Provincial Administration
was located 50 kilometers away in Pietermaritzburg. My colleagues in the Hospital were very
supportive. Patients received excellent
care and although we worked hard there were a few hours a day in the late
evening or early morning to pursue my ideas and thoughts. It was complete academic freedom and I built
a cohort of "eager beaver" doctors who shared my ideas and
enthusiasm.
I had a natural inquisitiveness and
spirit of enquiry. We would discuss the
new ideas during ward rounds, teaching or clinical meetings. And gradually the
brain storming would take form and create questions which needed answers.
New Ideas –the active incubator.
My first overseas trip was to plan
purchasing a new catheterization complex and the four major companies covered my trip at the end of 1968. My first stop was with CGR, the major French
x-ray company.
Paris was a strange experience. The cars traveled on the other side of the
road, and narrowly missed being hit by a car as I crossed the road. The hotel was very elegant, but there were no
side plates on the table at meals and one ate bread on the bare tablecloth. The language was impossible. Their radiological
equipment looked good, but the external finish not so good. The only comparable
unit had been installed in Pretoria.
I visited the local Hospital where Du
Bois had performed the first heart transplant and there I met Carpentier for
the first time.
My next stop was Einthoven in Holland. I
flew to Amsterdam and here I felt at home with the language. They sent an
elegant car to pick me up at the Airport with a very comfortable trip to
Einthoven.
This was a very professional visit as I
had developed their system with Roy Astley in Birmingham. We planned a biplane
room but I learnt all the new technical advances in X-ray tubes, image
intensifiers, gantries and cameras and spent two days with Buys at their Beta
site in Leiden.
The next stop was a few weeks with Elema
Schonander in Stockholm. It was
mid-winter. There was no sunshine. I commuted between the hotel and the
Karolinska Hospital and I can't remember that I visited the city. There was snow everywhere. The Karolinska was a very unusual hospital
and all their main meetings were conducted in English. Mannheim was the Director of Radiology. And the quality of all their work was
unusual. The chest x-rays showed the
most minute details of the lung parenchyma and the angiograms were perfect in
positioning, timing and quality. The
Karolinska was then the "mecca" of cardiac angriography due to the
excellence of the Elema-Schonander roll and cut film changers which could
photograph at up to 12 films a minute.
We bought one of their film changers and integrated it into our Phillips
angiographic suite.
The cardiologists worked under Bengt
Jonnson, pacemakers with Holmgren and surgery under Viking Bjiork. Bjiork was a most intense and restless man physically,
moving backwards and forwards at the meetings.
I had an opportunity to understudy each of them and come to know at
first hand some of the people (Edgar Mannheimer and Ulf Rudhe) who had studied
and written the cardiology of congenital
heart disease. At that time the Karolinska Hospital was the European
intellectual centre for the research and care of children with congenital heart
disease. It was an unusual educational experience. I came back to Durban with a new infusion of
knowledge and a close understanding of angiocrdiography and cardiac radiology.
My next visit was at the end of
1969. I spent two weeks in London
attending the meeting of the British Heart Society and a fortnight with John
Goodwin at the Hammersmith Hospital. It
was interesting to meet with him as a colleague rather than a teacher. He was interested in hypertrophic cardiomyopathy
and the different forms of pulmonary hypertension. We soon became close
friends. Celia Oakley had returned from the States and was active and voluble. The
ward rounds were active and full of active discussions.
I bought the new monographs in cardiology
and then continued to the American Heart Association Annual Meeting in
Chicago. This was my maiden trip to the
United States. It was mid-winter and
cold, but I was all eyes and ears at the meeting. It was held at the Hilton
Hotel in Chicago. I had never seen so many cardiologists bustling in the
entrance halls of the hotel. The lifts
were so congested that each entrance on the ground floor had a long queue with
its own individual concierge. The most interesting feature was the front row of
the lecture theatres with the giants of cardiology: Friedburg, Katz, Langendorf
and Pick who were experts at cross examining the lecturers.
This was the start of a series of medical
pilgrimages abroad. I traveled once a
year for six weeks living on budget of $2,000 which was the maximum that the
South African Government would allow for overseas travel. I managed in cheaper hotels and in London
stayed at the British Overseas Club. On my later trips I took Basil Lewis with
me as we could share accommodation and also saved on the budget.
I would always attend one of the major
American Cardiology Meetings and then chose a series of institutions where I
could learn and observe the latest inovations.
I went to the Cleveland Clinic regularly,
to learn and pick up tips from Mason Sones in coronary angiography and Floyd
Loop in cardiac surgery. Mason Sones was
a character. He was the first person to develop selective coronary angiography
and showed that a cardiologist could inject contrast medium directly into the
coronary arteries without damaging the coronary tree. He also had a special
relationship with Philips and he had the latest image amplifiers and patient
tables so that they could film the patient in different oblique projections.
His technicians showed me the finer points of modern photography and film
processing. I advanced my knowledge from the rudiments that I had learnt from
Roy Astley. Mason Sones worked nonstop, with clean gloves, no mask and a
cigarette between his lips. Basil would
blush at his language. He had perfect
eye-brain- finger coordination and it was a pleasure to watch his dexterity. In
the evenings we would review the angiograms, discuss the management of patients
and then he would phone their referring physician. His mind and personality were open and he was
always willing to share his ideas. Floyd Loop was another genius in the
operating room and taught me all about coronary artery surgery. This was a
brand new field and I took all the lessons back to Durban. My old friend from
Cape Town, John Viljoen, was head of cardiac anesthetics.
The Mayo Clinic was equally fascinating.
On my first visit I thought that Rochester was located near Minneapolis, but it
took a 2-hour bus ride to arrive at the Clinic in Rochester. This was a small town, occupied only by the
clinic and IBM Computers and a series of variably priced hotels and
motels. The patient would arrive in the
afternoon, see a cardiologist the next morning as an out-patient, undergo all
his tests on the same day without any unnecessary delay and then see his
physician again, who was free, on the following afternoon. Within 48 hours he would wrap up the
visit. If he needed in-patient care,
catheterization or surgery he would be admitted under the attending physician,
undergo a procedure by an expert on duty, and then the three physicians would
consult and decide on treatment. The clinic
physicians were chosen because of their ability to work as a team. I would make
rounds with the attending physicians, spend time in the cath lab and later in
the echo lab and attend the decision making meetings. It was also an opportunity to sit and read in
a very well stocked library. The Departments of Cardiology, Pediatric
Cardiology and Cardiac Surgery were very special. The Mayo clinic was then regarded as the acme
of heart disease in the United States, and the focal point of cardiac surgery. It
had the most intelligent and forward looking cardiac staff: Jeremy Swan, John
Kirklin, Dwight McGoon, du Shane, Wiedman, Burchell and Wood and many others.
This was the start of a regular pilgrimage and although many of the staff moved
to other centres, we remained close friends. Jeremy Swan had a grand vision, leadership,
wisdom and brilliance. He touched the lives of several generations of
cardiologists from all over the world and later put the Cedars-Sinai Division
of Cardiology in Los Angeles on the international map.
The Medical School at John Hopkins under Richard
Ross also had a galaxy of excellent cardiologists. It was less well organized than the other
units and the emphasis was on research.
The Helen Taussig Cardiac Center was another major center for congenital
heart disease and surgery.
Boston was the center of cardiology in
the United States. Gorlin was Chief of
Cardiology and Bernie Lown, the head of the coronary care unit, but my real
center of interest was Alex Nadas at the Children's Hospital. He was the doyen of Pediatric Cardiology and
had raised a generation of younger men.
The clinical material was unusual and Robert Gross who had operated on
the first ductus arteriosus was the senior surgeon. We had a very close personal relationship and
I would spend at least a week with him every year. He was a very fine mentor and would pass me
on to his younger colleagues. I spent hours in the clinics, cath lab, and
operating room and echo facilities. This was interlaced with interesting
discussions and I rarely returned to my hotel before 10pm. Normally I would
take home the latest cardiological journals and read and summarise the articles
and the day's activities until the early hours of the morning. I was an avarice
note taker and would revise the ideas several times until they were well
digested.
NIH in Washington was also very
interesting. Braunwald had already left
for San Diego, but we formed a close relationship with the pathologists: Bill
Roberts, the finest cardiac pathologist I have met and Victor Ferrans who was
one of the first exponents of the electron microscopy of the heart and who was very interested in congestive
cardiomyopathy. Again, they were very
interesting young doctors at NIH all of whom have risen to the top of US
cardiology. We had acquired an electron microscope in Durban and this was real
tutoring by the expert.
Seattle was a long distance away on the
Northwest Coast, but we visited Hal Dodge and Florence Sheehan to discuss the
measurement of ventricular function of the angiogram. Hal was quantitating
ventricular volumes and function with Sanders and was now pushing the details
of the left ventricular ejection fraction. Later in Jerusalem we used Sheehan's
techniques of measuring regional ventricular function. Again Hal was open and
showed us all his methods, current research and we spent hours of his precious
time discussing his new ideas. This was the basis of our later work on
myocardial salvage after thrombolysis in acute myocardial infarction. Greg
Brown was undertaking his first studies on quantitative coronary angiography
and we spent many hours studying his techniques which we later incorporated
into our studies.
Dudley Johnson was developing coronary
artery bypass surgery using venous grafts at St Lukes Hospital in Milwaukee and
we made several pilgrimages to watch him work. He used multiple grafts and
coronary endarterectomy and no patient was too ill for surgery. My whole
philosophy changed and he insisted on complete revascularization whenever
possible.
Jeremy Swan moved from the Mayo Clinic
and controlled Cedars-Sinai Hospital in Los Angeles. He had an expert team investigating acute myocardial
infarction. He had a large SCORE unit
and was paving the way to understand the hemodynamics of myocardial infarction.
When I arrived at the airport, he sent my old friend, Don Michael who was then
one of his young staff members with a
copy of his research protocols for the next three years so that I could
understand his thoughts and future research programs. I was astounded at his
openness, but he responded simply: my ideas are public property, even though
they are unpublished and I would like you to take them forward. He had a superb
group of associates
We also visited Richard Popp at Stanford
where the surgeons were undertaking the surgery of myocardial aneurysms. This was an opportunity to study and discuss
the practical implications of regional ventricular dysfunction.
We were having trouble with the
pacemakers. Cordis in Miami and
Medtronic in Minneapolis invited us to visit and this was an opportunity to
deepen my knowledge of their new units.
I lectured at all the Centers about our
latest research and would spend much time in the cath lab learning their techniques
and also in the operating room. I spent weeks in Houston with Denton Cooley marveling
at his ability to correct complex congenital hearts such as total anomalous
pulmonary venous drainage and transposition of the great arteries.
The foreign travel was a wonderful,
educational experience and kept me up to date with the latest
developments.
Jewish Durban
The Durban Jews formed a fairly unique
community. The first generation had been
poor merchants from Eastern Europe who became successful. Their children were well educated. Some followed their parents in their large
businesses. They were self employed.
Many had entered the professions:
pharmacists, accountants, lawyers and physicians. Very few worked for companies or other
employers: engineers or teachers. The Jew had his profession and his money in
the bank and was always ready to move. He was an independent spirit. Latent or overt anti-Semitism made them feel
uncertain and they were ready to move at a moment's notice. Many with young families were migrating to
Australia and Canada while those who could acquire a green card moved to the
United States. There were large enclaves
(settlements) in New York, Boca Raton, San Diego, Portland and Irvine. The older parents with established businesses
found it more difficult to move because of their very comfortable income.
The Jews were Friday Night synagogue
goers, who usually worked on Saturday unless there was a simcha and a large
Kiddush at the synagogue. Their children
went to the Jewish school and most of the families had Jewish circle of
friends. The children would have non
extravagant birthday parties and kept and celebrated the holidays at
school. Purim was a great festival and
the Pesach tradition was maintained.
The large Silverton Road synagogue became
our center of activity, and for the first time I was able to observe Shabbat. I was my own boss, controlled my time and
Shabbat was not dictated by the needs of the hospital. We simply transferred the academic activities
to Friday afternoons.
David Fine was the temporary Rabbi. A
genial man with a good training from Telze Yeshiva in Cleveland. A short time
later, Abner Weiss arrived as the new rabbi.
He had a dynamic personality, had trained as a teacher in Johannesburg,
and come to Durban North as the Reverend and teacher. The local congregation was very impressed
with his drive, knowledge and ability as an organizer and orator, and sent him
abroad to Kerem B'Yavne in Israel for 2 years to learn in an advanced yeshiva,
and followed this with 2 years at Yeshiva University, where he took his PhD in
Jewish Philosophy. His thesis was on the Maharal of Prague.
He was full of verve, running around with
his beard and tzitzit flying, and encouraging everyone who could share his
enthusiasm. I had previously joined the
"old man's shiur" in Durban where Rabbi Hertz taught Gemarah in
Yiddish.
This new wind of intellectual Judaism
swept me in its wake and for the first time I could embark on serious Jewish practice, participation and learning.
Abner
Weiss established a series of study circles where he taught simple Judaism and
Philosophy during the week and on Saturdays had an extensive learning program
at the synagogue. He was also appointed
as professor of Hebrew at the University of Natal in Durban and ran a very
stimulating program. His classes were
well attended. He opened a language
laboratory based on the American Foreign Service Hebrew Language Program and I
would spend a few hours a week in the laboratory. I copied many of the tapes
and would replay them in my car as I commuted to and fro from home to the
hospital. Unfortunately the language became on oral experience and I was fluent
in conversation but never learned to read and write correctly. Later I used my
secretaries to overcome this deficiency.
The community was revitalized by his
enthusiasm and it was interesting how a single person could change the
community.
There was a weekly Hebrew ulpan where Mr.
Zimmerman the local Hebrew School teacher had been teaching the diehards for
many years and later, Mr. Fischer, the local Hebrew book seller took his place.
I joined the group. We mastered the standard textbook, "1000
Words in Hebrew". In addition, Avi Bakst and I had our own personal shiur
with the local lecturer in Hebrew at the University.
General Internal Medicine
King Edward VIII Hospital was a large non
white regional hospital which was converted into the main teaching hospital. It was very well kept and provided excellent
primary, secondary and tertiary medical care.
It was overpopulated and a little understaffed by a very good dedicated
group of care givers.
I looked after a small 15-bed unit in the
main professorial unit, but gradually the residents filled it with patients who
had heart failure, high blood pressure and kidney disease. It was good to be in the main teaching
hospital but my time was very limited.
We had a weekly cardiac out patient clinic of about 60 patients every
Wednesday afternoon where I would be joined by 2 or 3 of my medical registrars
and staff from Wentworth Hospital. The pathology was varied; the patients were
sick and complicated but the management was very rewarding.
Addington Hospital was a large modern
hospital on the beach front. It received
white patients who could not afford the private hospitals. Again, the standards were very high, but I
did not have the time to participate in their programs.
The period in Durban was probably the
most productive in my life. I had
started with a tiny department, developed one of the best departments in the country
and left it in excellent condition. It
was far from the major academic centers in South Africa, but the traveling,
constant reading and full time thinking allowed me to provide a high standard
of clinical service and the freedom to think, research and write.
The Winds of Change
I could have continued in Durban much
longer, but the political turmoil, the racial inequality and the undercurrents
of revolution made me restless and pushed me towards Israel. My latent Zionism would at last reach
fruition.
December 1971 brought the next major change. Ciba -Geigy the major pharmaceutical company in Basle had developed a third generaion Beta Sympathetic blocking drug with minor innate sympthetic action to prevent toxic side effects from overdosing had asked us to study its effects in man in hypertensive patients and the results were very satsfactory. When the study was cmpleted the company inted me to send a monthe in Basle to explain the results to their scientic and Medical staff in Basle, I asked them to permit me to spend part of the period as a Sabattical at Hadassah Hospital in Jerusalem.Hadassah were very generous and offered me a small guest apartment in the Hospital. I arrived with Craig who was then 7 years old. I used my time carefully, making rounds of the in-patients,teaching the students and residents and interacting with the Medical Staff. I made agood impression on the Medical ,Surgical and Anaesthetic staff and after two months the Hadassah and Medical school administration set up a Search Commitee to look for a new Head of Cardiology. I was interviewd and then the formal appointment progam started rolling, I returned to Durban and decided to bring Basil Lewis and Avy Bakst with me to Hadassah. The appointment process continued and finally the final the appintment was ratified.
I left the in July 1973, Dr.
Elliot Chesler arrived from Cape Town to take my place. He was good but did not stay for a long
period and after 3-4 years took up a new appointment as Head of Cardiology at
the Veterans Administration Hospital in Minneapolis.
Dr. Abdul Mitha, one of my trainees, took
over from him. The "winds of
change" removed the white supremacy from South Africa. The priorities of medical care changed with
an emphasis on primary family medicine and less emphasis on specialized medical
care. Cardiology and cardiothoracic
surgery were relocated in a new teaching hospital and Wentworth was converted
into a primary care facility. The good work continued but the pace and the
priorities changed.
I had learned to lead a department,
mentor trainees, navigate unknown territories and provide outstanding medical,
care, teaching and research and now it was time to move on to undertake new challenges.